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2014/02~2017/06 慈濟大學 醫學科學研究所 博士
2004/09~2006/06 慈濟大學 生物化學研究所 碩士
1998/09~2002/06 慈濟大學 醫學檢驗暨生物技術學系 學士
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2002/07~2005/08 慈濟骨髓幹細胞中心技術員
2006/08~2017/04 花蓮慈濟醫院檢驗醫學科醫檢師
2017/05~2017/07 花蓮慈濟醫院檢驗醫學科血清免疫組長
2017/08~ 花蓮慈濟醫院檢驗醫學科主任
2020/08~ 慈濟大學醫學檢驗暨生物技術學系助理教授
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1. Clinical immunoserology and biochemistry
2. Drug design and molecular docking
3. Molecular modeling
4. Cell signal transduction
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1.Shinn-Jong Jiang, Je-Wen Liou, Chun-Chun Chang, Yi Chung, Lee-Fong Lin and Hao-Jen Hsu (2015, Dec). Peptides derived from CXCL8 based on in silico analysis inhibit CXCL8 interactions with its receptor CXCR1. Scientific Reports, 5:18638, 1-14. (SCI).
2.Chun-Chun Chang, Hao-Jen Hsu, Jui-Hung Yen, Shih-Yen Lo， Je-Wen Liou (2017, May). A Sequence in the loop domain of hepatitis C virus E2 protein identified in silico as crucial for the selective binding to human CD81. PLoS One, 2017,12(5): e0177383. (SCI)
3.Shinn-Jong Jiang, Pei-I TSAI, Shih-Yi Peng, Chun-Chun Chang, Yi Chung, Hao-Hsiang Tsao, Hsin-Ting Huang, San-Yuan Chen, and Hao-Jen Hsu (2019, Feb) A potential peptide derived from cytokine receptors can bind proinflammatory cytokines as a therapeutic strategy for anti-inflammation. Scientific Reports, 2019, 9: 2317. (SCI)
4.Chun‑Chun Chang, Cheng‑Der Liu, Sheng‑Feng Pan, Wei‑Han Huang, Chih‑Wen Peng and Hao‑Jen Hsu. (2020, Jul) Targeting of interleukin‑10 receptor by a potential human interleukin‑10 peptide efficiently blocks interleukin‑10 pathway‑dependent cell proliferation. Tzu Chi Medical Journal, 32(3): 245–253.
5.Chun-Chun Chang, Je-Wen Liou, Kingsley Theras Primus Dass, Ya-Tzu Li, Shinn-Jong Jiang, Sheng-Feng Pan, Yu-Chen Yeh, and Hao-Jen Hsu. (2020, Oct) Internal water channel formation in CXCR4 is crucial for Gi-protein coupling upon activation by CXCL12. Communications Chemistry, 3:133. (SCI)
6.Cheng‑Der Liu, Chun‑Chun Chang, Wei‑Han Huang. (2020, Dec). The perspectives of interleukin‑10 in the pathogenesis and therapeutics of multiple myeloma. Tzu Chi Medical Journal. 33(3):257-262.
7.Ming-Chun Chen, Yu-Chao Hsiao, Chun-Chun Chang, Sheng-Feng Pan, Chih-Wen Peng, Ya-Tzu Li, Cheng-Der Liu, Je-Wen Liou, and Hao-Jen Hsu. (2021, Mar) Valine-279 Deletion–Mutation on Arginine Vasopressin Receptor 2 Causes Obstruction in G-Protein Binding Site: A Clinical Nephrogenic Diabetes Insipidus Case and Its Sub-Molecular Pathogenic Analysis. Biomedicines, 9: 301. (SCI)
8.Hemalatha Mani, Jui‑Hung Yen, Hao‑Jen Hsu, Chun‑Chun Chang, Je‑Wen Liou. (2022, Apr) Hepatitis C virus core protein: Not just a nucleocapsid building block, but an immunity and inflammation modulator. Tzu Chi Medical Journal. 34 (2): 139-147.
9.Chun-Chun Chang, Sheng-Feng Pan, Min-Huang Wu, Chun-Tse Cheng, Yan-Rui Su, Shinn-Jong Jiang, and Hao-Jen Hsu. (2022, Jan). Combinatorial Virtual Screening Revealed a Novel Scaffold for TNKS Inhibition to Combat Colorectal Cancer. Biomedicines, 10, 143. (SCI)
10.Chun-Chun Chang, Shih-Yi Peng, Hao-Hsiang Tsao, Hsin-Ting Huang, Xing-Yan Lai, Hao-Jen Hsu, Shinn-Jong Jiang. (2022, Mar). A multitarget therapeutic peptide derived from cytokine receptors based on in silico analysis alleviates cytokine-stimulated inflammation. Frontiers in Pharmacology, 13:853818. (SCI)
11.Chun-Chun Chang, Hao-Jen Hsu, Tien-Yuan Wu and Je-Wen Liou. (2022, Jun) Computer-aided discovery, design, and investigation of COVID-19 therapeutics. Tzu Chi Medical Journal. 34 (3): 276-286
12.Yeh-Hsin Yu, Te-Jung Wang, Chun-Chun Chang. (2022, Jun) Using OSCE to Assess Blood Collection and Doctor– Patient Communication for Medical Laboratory Scientist Interns at a Medical Center in Eastern Taiwan. Journal of Taiwan Simulation Society in Healthcare. 9 (1): 18-31.
13.Meng-Ju Wu, Pei-Shan Li, Shu-Chen Chen, Ming-Huei Gu, Kae-Maw Wang, Jun-Xiong Peng, Teng- Ying Lin, Chun-Chun Chang. (2023, Sep) Integrate information to optimize sample collection process and simplify and monitor the clinical laboratory examination process. Journal of Biomedical & Laboratory Sciences. 35 (3):121-130
14.Chun-Ming Chang, Chun-Chun Chang, Ho Yin Pekkle Lam, Shih-Yi Peng, Yi-Hsuan Lai,Bi-Da Hsiang,Yu-Yi Liao, Hao-Jen Hsu and Shinn-Jong Jiang. (2023, Sep) Therapeutic Peptide RF16 Derived from CXCL8 Inhibits MDA-MB-231 Cell Invasion and Metastasis. International Journal of Molecular Sciences. 2023, 24(18), 14029. (SCI)
15.Hemalatha Mani, Chun-Chun Chang, Hao-Jen Hsu, Chin-Hao Yang, Jui-Hung Yen and Je-Wen Liou. (2023 Aug) Comparison, Analysis, and Molecular Dynamics Simulations of Structures of a Viral Protein Modeled Using Various Computational Tools. Bioengineering. 2023, 24;10(9):1004.
16.Chun-Chun Chang, Chin-Hao Yang, Chin-Hsien Chuang, Shinn-Jong Jiang, Yin-Min Hwang, Je-Wen Liou & Hao-Jen Hsu. (2023, Dec) A peptide derived from interleukin-10 exhibits potential anticancer activity and can facilitate cell targeting of gold nanoparticles loaded with anticancer therapeutics. Communications Chemistry. 2023 Dec 15;6(1):278 (SCI)
17.Yen, Jui-Hung, Chang, Chun-Chun; Hsu, Hao-Jend, Yang, Chin-Haoe; Mani, Hemalathae; Liou, Je-Wen. (2024, Jul) C-X-C motif chemokine ligand 12—C-X-C chemokine receptor type 4 signaling axis in cancer and the development of chemotherapeutic molecules. Tzu Chi Medical Journal 36(3):p 231-239.
18.Kai-Yun Su, Jing-Chun Huang, Jing- Yi Lin, and Chun-Chun Chang. (2024, Sep) Evaluation of leukocyte depletion of packed red blood cell for the prevention of clinically observed transfusion reactions at a medical center in Eastern Taiwan. Tzu Chi Medical Journal 3;37(1):109-115.
19.Hao-Jen Hsu, Ya-Tzu Li, Xing-Yan Lai, Yu-Chen Yeh, Ting-Yu Hu, Chun-Chun Chang. (2024, Oct) State transitions of coupled Gi-protein: Insights into internal water channel dynamics within dopamine receptor D3 from in silico submolecular analyses. International Journal of Biological Macromolecules. 281 (2024) 136283. (SCI)
20.Chin-Hao Yang, Hao-Jen Hsu, Je-Wen Liou, Guan-Ting Chen, Xing-Yan Lai, Chin-Hsien Chuang, Chun-Chun Chang (2024, Dec) An in silico designed peptide-loaded hydrogel is able to accelerate the healing of bacteria-infected wounds in mice. Materials Today Chemistry. 43 (2025) 102478. (SCI)
21.Chun-Chun Chang, Hsuan-Yu Tu, Shih-Yi Peng, Hao-Jen Hsu and Shinn-Jong Jiang (2025 Jul) Unveiling the anti-inflammatory potential of RF16, an interleukin 8-derived therapeutic peptide in macrophages. Journal of Inflammation 28;22(1):29 (SCI)
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Research fields:
1. Ligand-receptor interactions-based peptide drug design
The bioinformatics and structure database have been used to design new peptide drugs which have better affinity than native proteins to trigger or inhibit the signal transduction cascade. We have developed an efficient method on peptide drug design, which combines theoretical calculations (molecular docking and MM/PBSA binding free energy calculation) and in vitro experiments (cellular assays and SPR measurements) for validation. The method has been applied to develop functional peptides and the results were also published on the SCI journals; for example, CXCL8-CXCR4, CD81-HCV E2, and cytokines-cytokine receptors.
Scientific Reports, 5:18638 (2015); PLoS One, 12(5): e0177383 (2017);Scientific Reports, 9:2317 (2019); TCMJ 32(3):245-253 (2020);Materials Today Chemistry. 43 (2025) 102478.
(社團法人台灣醫檢學會110年度優秀青年論文獎基礎研究組)
2. Deep learning-based interpretation of Gram-stained images 藉由與醫學資訊與生物資訊相關之老師合作開發以深度學習為基礎之革蘭氏染色抹片影像之判讀，我們嘗試了數種不同卷積神經網路(CNN)模型，如基本的卷積神經網路(FlatNet)、殘差神經網路(ResNet)、GoogleNet等，來進行模型訓練比較。初步結果顯示在十萬多張經分類標記的影像中，以殘差神經網路(ResNet)的準確率最高，進一步分析在五種主要分類菌群(GPC、GPB、GNB、GPC in chain、Yeast)的平均分析準確率達到97.5%。未來將持續增加原始抹片檢體影像數量及嘗試其他神經網路模型，並佐以調整參數、層數等以獲得最佳辨識效果，並擴展至其他不同來源體液之革蘭氏抹片影像、分類辨識更多菌種及相關專利之申請。
The 14th Chinese Laboratory Medicine Conference, Taipei, Taiwan (2019). (Bio-Rad 醫學檢驗論文獎)
3.GPCR binding and activation mechanism
We have used several different simulation methods, such as conventional MD, steer MD (SMD), and accelerated MD (flooding) to study the initial binding and activation mechanisms of GPCR. At current stage, we focus on chemokine receptors, CXCR1, CXCR4, and CCR7. We also found the continuous internal water pathway formation for DA-D3R-Gi and CXCL12-CXCR4-Gi tricomplex active structure systems, consistent with previous simulations. The findings of our studies provide dynamic atomic-level insight and prove valuable in drug design for the treatment of GPCR-related diseases.
PLoS One 9(4), e94178 (2014); Scientific Reports 7:12792 (2017); Communications Chemistry 3, 133 (2020); Biomedicines, 9:301 (2021); International Journal of Biological Macromolecules. 281 (2024) 136283.
(社團法人台灣醫檢學會113年度學術論文獎基礎研究組)
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e-mail: chunchun@tzuchi.com.tw
phone: 03-8561825#13952-202
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