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劉哲文 教授
Professor Je-Wen Liou, B.Sc., M.Sc., Ph.D.
慈濟大學 醫學系生化學科/醫學檢驗生物技術學系/生物醫學暨工程學系/醫學科學研究所
Department of Biochemistry, School of Medicine
Ph.D. Imperial College London (UK)
M.Sc. National Taiwan University (Taiwan)
B.Sc. National Taiwan University (Taiwan)
實驗室網頁: https://sites.google.com/view/je-wen-liou/home
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英國倫敦帝國學院博士(生物化學)
國立台灣大學碩士(應用微生物)
國立台灣大學學士(農業化學)
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慈濟大學 教務長
慈濟大學 醫學系生化學科 教授
慈濟大學 醫學檢驗生物科技學系 合聘教授
慈濟大學 教師發展暨教學資源中心 主任
慈濟大學 國際長
慈濟大學 教務處課務組 組長
慈濟大學 教資中心教師專業組 組長
慈濟大學 醫學系生化學科 副教授
慈濟大學 醫學科學研究所 合聘副教授
慈濟大學 醫學檢驗生物技術學系 合聘副教授
國立東華大學 奈米科技研究中心 合聘副教授
慈濟大學 醫學系生化學科 助理教授
英國 倫敦帝國學院 化學系 博士後研究員
海軍陸戰隊 步兵加強營 少尉排長
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生物化學; 生物物理學; 奈米生物醫學; 醫學影像技術; 奈米材料; 生物資訊學; 蛋白質化學; 病毒學.
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近年期刊論文 Recent Journal Publications:
Liou JW, Chen PY, Gao WY, Yen JH.(2024) Natural phytochemicals as small-molecule proprotein convertase subtilisin/kexin type 9 inhibitors. Tzu Chi Med J. 6(4):360-369 (ESCI, PubMed). 本人為第一作者.
Yen JH, Keak PY, Wu CL, Chen HJ, Gao WY, Liou JW, Chen YR, Lin LI, Chen PY. (2024) Shikonin, a natural naphthoquinone phytochemical, exerts anti-leukemia effects in human CBF-AML cell lines and zebrafish xenograft models. Biomedicine & Pharmacotherapy. 179:117395 (SCI).
Chin CY, Huang WT, Wang JH, Liou JW, Hsu HJ, Chen MC. (2024) Overview of clinical status, treatment, and long-term outcomes of pediatric autosomal-dominant polycystic kidney disease: a nationwide survey in Taiwan. Scientific Reports. 14(1):16280 (SCI).
Yen JH, Chang CC, Hsu HJ, Yang CH, Mani H, Liou JW*. (2024 Jul) C-X-C motif chemokine ligand 12—C-X-C chemokine receptor type 4 signaling axis in cancer and the development of chemotherapeutic molecules. Tzu Chi Medical Journal. 36(3): 231-239. (ESCI). 本人為通訊作者.
Gao WY, Chen PY, Hsu HJ, Liou JW, Wu CL, Wu MJ, Yen JH. (2024 Apr) Xanthohumol, a prenylated chalcone, regulates lipid metabolism by modulating the LXRα/RXR-ANGPTL3-LPL axis in hepatic cell lines and high-fat diet-fed zebrafish models. Biomedicine & Pharmacotherapy. 174:116598. (SCI)
Hsu PH, Hazam PK, Huang YP, Yeh JC, Chen YR, Li CC, Chang CF*, Liou JW*, Chen JY* (2024 Jan) Sequential rearrangement and stereochemical reorganization to design an antimicrobial peptide with enhanced stability. Biomedicine & Pharmacotherapy. 170: 116088. (SCI). 本人為通訊作者.
Hsu PH, Hazam PK, Huang YP, Yeh JC, Chen YR, Li CC, Chang CF*, Liou JW*, Chen JY* (2024 Feb) Optimization of sequence and chiral content enhances therapeutic potential of tilapia piscidin peptides. Eur J Med Chem. 265:116083. (SCI). 本人為通訊作者.
Chang CC, Yang CH, Chuang CH, Jiang SJ, Hwang YM, Liou JW*, Hsu HJ* (2023 Dec) A peptide derived from interleukin-10 exhibits potential anticancer activity and can facilitate cell targeting of gold nanoparticles loaded with anticancer therapeutics. Communications Chemistry. 6(1):278. (SCI). 本人為通訊作者.
Chen PY, Lin CY, Wu CL, Keak PY, Liou JW, Gao WY, Lin LI, Yen JH (2023 Sep) Pinostrobin modulates FOXO3 expression, nuclear localization, and exerts antileukemic effects in AML cells and zebrafish xenografts. Chemico-Biological Interactions. 385, 110729 (SCI).
Chang PR, Liou JW, Chen PY, Gao WY, Wu CL, Wu MJ, Yen JH (2023 Sep) The Neuroprotective Effects of Flavonoid Fisetin against Corticosterone-Induced Cell Death through Modulation of ERK, p38, and PI3K/Akt/FOXO3a-Dependent Pathways in PC12 Cells. Pharmaceutics. 15(10): 2376 (SCI). 本人為第一作者.
Mani H, Chang CC, Hsu HJ, Yang CH, Yen JH, Liou JW* (2023 Aug) Comparison, Analysis, and Molecular Dynamics Simulations of Structures of a Viral Protein Modeled Using Various Computational Tools. Bioengineering. 10(9): 1004 (SCI). 本人為通訊作者.
Wu IC, Liou JW, Yang CH, Chen JH, Chen KY, Hung CH (2023 Jul) Self-assembly of gelatin and collagen in the polyvinyl alcohol substrate and its influence on cell adhesion, proliferation, shape, spreading and differentiation. Frontiers in Bioengineering and Biotechnology. 11:1193849 (SCI).
Lo KM, Lin YS, Liou JW, Chiu TC, Hu CC (2023 Jun) Electrochemically synthesized green fluorescent carbon dots for quantitation of hypochlorite and carbendazim. J Food Drug Anal.31(2):244-253 (SCI).
Fang ST, Huang SH, Yang CH, Liou JW, Mani H, Chen YC (2022 Dec) Effects of Calcium Ions on the Antimicrobial Activity of Gramicidin A. Biomolecules. 12(12):1799 (SCI).
Chang CC, Hsu HJ, Wu TY, Liou JW* (2022 Mar) Computer-aided discovery, design, and investigation of COVID-19 therapeutics. Tzu Chi Medical Journal. 34(3):276-286 (ESCI; PubMed). 本人為通訊作者.
Liou JW, Mani H, Yen JH (2022 Mar) Viral Hepatitis, Cholesterol Metabolism, and Cholesterol-Lowering Natural Compounds. Int J Mol Sci. 23(7):3897 (SCI). 本人為第一作者.
Mani H., Yen JH, Hsu HJ, Chang CC, Liou JW* (2022) Hepatitis C virus core protein: Not just a nucleocapsid building block, but an immunity and inflammation modulator. Tzu Chi Medical Journal. 34(2):139-147 (ESCI; PubMed). 本人為通訊作者.
Chen PY, Gao WY, Liou JW, Lin CY, Wu MJ, Yen JH (2021 Jul) Angiopoietin-Like Protein 3 (ANGPTL3) Modulates Lipoprotein Metabolism and Dyslipidemia. Int J Mol Sci. 22(14):7310 (SCI).
Chen MC, Hsiao YC, Chang CC, Pan SF, Peng CW, Li YT, Liu CD, Liou JW*, Hsu HJ (2021 Mar) Valine-279 Deletion-Mutation on Arginine Vasopressin Receptor 2 Causes Obstruction in G-Protein Binding Site: A Clinical Nephrogenic Diabetes Insipidus Case and Its Sub-Molecular Pathogenic Analysis. Biomedicines; 9(3):301 (SCI). 本人為通訊作者.
Mani H, Chen YC, Chen YK, Liu WL, Lo SY, Lin SH, Liou JW* (2021 Mar) Nanosized Particles Assembled by a Recombinant Virus Protein Are Able to Encapsulate Negatively Charged Molecules and Structured RNA. Polymers; 13(6):858. (SCI). 本人為通訊作者.
Chun-Chun Chang, Je-Wen Liou, Kingsley Theras Primus Dass, Ya-Tzu Li, Shinn-Jong Jiang, Sheng-Feng Pan, Yu-Chen Yeh, Hao-Jen Hsu (2020, Oct). Internal water channel formation in CXCR4 is crucial for Gi-protein coupling upon activation by CXCL12. Communications Chemistry, 3: 133. (SCI). 本人為第一作者.
Chin-Hao Yang, Yi-Cheng Chen, Shih-Yi Peng, Andy Po-Yi Tsai, Tony Jer-Fu Lee, Jui-Hung Yen, Je-Wen Liou (2018, Oct). An engineered arginine-rich αhelical antimicrobial peptide exhibits broad-spectrum bactericidal activity against pathogenic bacteria and reduces bacterial infections in mice. Scientific Reports, 8: 14602. (SCI). 本人為通訊作者.
Chun Chieh Tseng, Pei Ying Yu, Je Wen Liou, Kai Chih Chang (2018, Jun). Altered susceptibility to air sampling stress by filtration is related to colistin resistance development in Acinetobacter baumannii. Indoor Air, 28: 732-743. (SCI).
Chun-Chun Chang, Hao-Jen Hsu, Jui-Hung Yen, Shih-Yen Lo, Je-Wen Liou (2017, May). A Sequence in the loop domain of hepatitis C virus E2 protein identified in silico as crucial for the selective binding to human CD81. PLoS One, 12(5): e0177383. (SCI). 本人為通訊作者.
Chin-Jung Chuang, Cheng-Der Liu, Ranjit A. Patil, Chi-Chung Wu, Yao-Chih Chang, Chih-Wen Peng, Ting-Kwuan Chao, Je-Wen Liou, Yung Liou, Yuan-Ron Ma (2016, Dec). Impact of cuticle photoluminescence on the color morphism of a male damselfly Ischnura senegalensis (Rambur, 1842). Scientific Reports, 6: 38051. (SCI).
Chun-Chieh Tseng, Yun-Hsuan Tsai, Anren Hu, Je-Wen Liou, Kai-Chih Chang, Hsin-Hou Chang (2016, Oct). Altered susceptibility to the bactericidal effect of photocatalyticoxidation by TiO2 is related to colistin resistance development in Acinetobacter baumannii. Applied Microbiology and Biotechnology, 100(19):8549-61. (SCI).
Huai-Yi Chen, Hwa-Ming Nieh, Ming-Feng Yang, Yu-Kung Chou, Jui-Hsu Chung, Je-Wen Liou (2016, Aug). Implementation of a Low-Cost Automated LED Photometer for Enzymatic Reaction Detection to Teach Basic Bioelectronics Technologies in Vocational High Schools. IEEE Transactions on Education, 59(3): 194-201. (SCI).
Chih-Lung Shen, Cheng-Der Liu, Ren-In You, Yung-Hao Ching, Jun Liang, Liangru Ke, Ya-Lin Chen, Hong-Chi Chen, Hao-Jen Hsu, Je-Wen Liou, Elliott Kieff, Chih-Wen Peng (2016, Feb). Ribosome Protein L4 is essential for Epstein–Barr Virus Nuclear Antigen 1 function. Proc. Natl. Acad. Sci. U.S.A., 113(8):2229-2234. (SCI).
Sheng-Yao Hsu, Je-Wen Liou, Tsung-Lin Cheng, Shih-Yi Peng, Chi-Chen Lin,Yuan-Yuan Chu, Wei-Cheng Luo, Zheng-Kai Huang, Shinn-Jong Jiang (2015, Dec). beta-Naphthoflavone protects from peritonitis by reducing TNFalpha-induced endothelial cell activation. Pharmacological Research, 102: 192-199. (SCI).
Shinn-Jong Jiang, Je-Wen Liou, Chun-Chun Chang, Yi Chung, Lee-Fong Lin,Hao-Jen Hsu (2015, Dec). Peptides derived from CXCL8 based on in silico analysis inhibit CXCL8 interactions with its receptor CXCR1. Scientific Reports, 5:18638. (SCI).
Je-Wen Liou, Yu-Jiun Hung, Chin-Hao Yang, Yi-Cheng Chen (2015, Jan). The Antimicrobial Activity of Gramicidin A Is Associated with Hydroxyl Radical Formation. PLoS ONE, 10(1): e0117065. (SCI). 本人為第一作者.
Liou JW, Chang FT, Chung Y, Chen WY, Fischer WB, Hsu HJ (2014, Apr). In silico analysis reveals sequential interactions and protein conformational changes during the binding of chemokine CXCL-8 to its receptor CXCR1. PLoS One, 9(4):e94178. (SCI) 本人為第一作者.
Chang KC, Cheng SJ, Chen YC, Huang HR, Liou JW (2013 Dec). Nanoscopic analysis on pH induced morphological changes of flagella in Escherichia coli. J Microbiol Immunol Infect, 46(6):405-12. (SCI) 本人為通訊作者.
Kai-Chih Chang, Yu-Wei Chiang, Chin-Hao Yang, Je-Wen Liou (2012, Dec). Atomic force microscopy in biology and biomedicine. Tzu Chi Medical Journal, 24(4):162-169. (ESCI; Scopus) 本人為通訊作者.
Liou JW, Chang HH (2012, Aug).Bactericidal effects and mechanisms of visible light-responsive titanium dioxide photocatalysts on pathogenic bacteria. Arch. Immunol. Ther. Exp. (Warsz), 60(4):267-75. (SCI) 本人為第一作者.
Liou JW, Gu MH, Chen YK, Chen WY, Chen YC, Tseng YH, Hung YJ, Chang HH (2011, May). Visible light responsive photocatalyst induces progressive and apical-terminus preferential damages on Escherichia coli surfaces. PLoS One, 6(5):e19982. (SCI) 本人為第一作者.
Kumar VB, Yuan TC, Liou JW, Yang CJ, Sung PJ, Weng CF (2011) Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles. Mutat Res. 707(1-2):42-52. (SCI)
Chan SC, Lo SY, Liou JW, Lin MC, Syu CL, Lai MJ, Chen YC, Li HC (2011) Visualization of the structures of the hepatitis C virus replication complex. Biochem Biophys Res Commun. 404(1):574-8. (SCI)
Liou JW, Mulet X, Klug DR (2002) Absolute measurement of phosphorylation levels in a biological membrane using atomic force microscopy: the creation of phosphorylation maps. Biochemistry. 41(27):8535-9. (SCI). 本人為第一作者.
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抗菌抗癌胜肽藥物開發; 病毒蛋白體學; 奈米生物化學; 奈米影像技術; 生物分子結構; 生物材料工程.
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慈濟大學 107學年度 優良全英語課程獎勵.
慈濟大學 104學年度 校級教學優良教師.
慈濟大學 101學年度 校級教學優良教師.
慈濟大學 99學年度 院級教學優良教師.
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