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本實驗室主要進行寄生蟲(曼森血吸蟲與廣東住血線蟲為主) 的相關研究為主。研究主題包含中草藥抗寄生蟲感染、寄生蟲免疫(包含免疫調控、發炎、細胞凋亡) 、肝纖維化及寄生蟲疫苗與治療等。代表成果包含五味子乙素(Schisandrin)-praizquantel共同治療曼森血吸蟲症相關研究(2021發表)。五味子乙素(Schisandrin B)-阿苯達唑(Albendazole) 混合治療廣東住血線蟲感染引發之小鼠腦膜炎(2020發表); 與中國預防研究院合作研究的白藜蘆醇對血吸蟲感染引發之纖維化的作用機制(2019發表); 與臺北醫學大學寄生蟲科合作的姬松茸的治療血吸蟲感染(2019發表);另外蔓荊子黃素(Casticin) 對曼森血吸蟲感染引發的抗纖維化和抗血吸蟲病作用的相關研究也已在進行投稿。 再加上本實驗室獨立完成發表的血吸蟲感染引起的小鼠肝臟粒線體的動態變化及肝臟的發炎因子變化;及廣東住血線蟲感染引發的小鼠腦部粒線體的動態變化及腦部的發炎因子變化。這些成果都可應用於對抗肝臟纖維化、腦部發炎及提供寄生蟲防治一種新的臨床治療方式或更進一步的研究方向。
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服務機關 服務單位 職稱 起迄年月
現職：慈濟大學 醫學系生化科 教授 111/2至 迄今
經歷：慈濟大學 醫學系生化科 副教授 105/2至 111/2
慈濟大學 醫學系生化科 助理教授 101/8至105/2
慈濟大學 醫學系實驗診斷科 助理教授 98/8至101/7
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寄生蟲學, 熱帶醫學, 寄生蟲免疫學,寄生蟲診斷學
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近五年著作
1. Ho Yin Pekkle Lam, Shu-Ping Huang, Ting-Ruei Liang, Wen-Jui Wu, Po-Ching Cheng, Kai-Chih Chang*, Shih-Yi Peng* (2022, Feb). Increased immunogenicity and protection of recombinant Sm14 antigens by heat-killed Cutibacterium acnes in BALB/c mice infected with Schistosoma mansoni. Parasitology International , 86, 102446; 1-7. 本人為通訊作者.
2. Ho Yin Pekkle Lam, Po-Ching Cheng*, Shih-Yi Peng* (2021, Dec). Resolution of systemic complications in Schistosoma mansoni infected mice by concomitant treatment with praziquantel and Schisandrin B. International Journal for Parasitology, 21:003155. 本人為通訊作者.
3. Ho Yin Pekkle Lam, Ting-Hua Yang, Ting-Ruei Liang, Po-Ching Cheng, KaiChih Chang*, Shih-Yi Peng* (2021, Oct). Heat-killed Propionibacterium acnes augment the protective effect of 28-kDa glutathione S-transferases antigen against Schistosoma mansoni infection. Acta Tropica, 222, 106033; 1-9. 本人為 通訊作者.
4. Chen-Hsun Ho, Chia-Hsiung Cheng, Tzu-Wen Huang, Shih-Yi Peng*, Kin-Mu Lee, Po-Ching Cheng* (2021, Jul). Switched phenotypes of macrophages during the different stages of Schistosoma japonicum infection influenced the subsequent trends of immune responses. Journal of Microbiology, Immunology and Infection, 1-24. 本人為通訊作者.
5. Ho Yin Pekkle Lam, Meng-Jiun Lai, Ting-Yu Chen, Wen-Jui Wu, Shih-Yi Peng* and Kai-Chih Chang* (2021, Jun). Therapeutic Effect of a Newly Isolated Lytic Bacteriophage against Multi-Drug-Resistant Cutibacterium acnes Infection in Mice. International Journal of Molecular Sciences , 22:7031-7031. 本人為通訊 作者.
6. Ho Yin Pekkle Lam, Ting-Ruei Liang, Shih-Yi Peng* (2021, Jun). Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo. PLOS Neglected Tropical Diseases, 15(6); 1-24. 本人為通訊作者.
7. Ho Yin Pekkle Lam, Ting-Ruei Liang, Yi-Chia Lan,Kai-Chih Chang, Po-Ching Cheng, Shih-Yi Peng* (2021, Jun). Antifibrotic and anthelminthic effect of casticin on Schistosoma mansoni-infected BALB/c mice. Journal of Microbiology, Immunology and Infection, 1-9. 本人為通訊作者.
8. Ho Yin Pekkle Lam, Cheng-Chi Chen, Tina Tu-Wen Chen, Kai-Chih Chang, Wen-Jui Wu, Ting-Hua Yang, Ting-Ruei Liang, Po-Ching Cheng, Shih-Yi Peng (2020, Nov). Mitochondrial dynamics in Angiostrongylus cantonensis-infected mouse brain. parasitology International, 80:102231. 本人為通訊作者.
9. Ho Yin Pekkle Lam, Tina Tu-Wen Chen, Cheng-Chi Chen, Ting-Hua Yang, PoChing Cheng, Shih-Yi Peng (2020, Aug). Angiostrongylus cantonensis activates inflammasomes in meningoencephalitic BALB/c mice. Parasitology International , 77:102119. 本人為通訊作者.
10. Ho Yin Pekkle Lam, Ting-Ruei Liang, Shinn-Jong Jiang, Shih-Yi Peng (2020, Jul). Albendazole-Schisandrin B co-therapy on Angiostrongylus cantonensis induced meningoencephalitis in mice. Biomolecules, 10(7):1001. 本人為通訊作者.
11. Ho Yin Pekkle Lam, Tina Tu-Wen Chen, Yu-Chuan Tseng, Kai-Chih Chang, Ting-Hua Yang, Shih-Yi Peng (2020, Jun). Detection and genotyping of Giardia duodenalis from cattle and pigs in Hualien country, Eastern Taiwan. Journal of Microbiology, Immunology and Infection, (20)30123-7. 本人為通訊作者.
12. Shih-Yi Peng, Li-Kuang Chen, Wen-Jui Wu, Prajna Paramita, Po-Wei Yang, YunZhong Li, Meng-Jiun Lai, Kai-Chih Chang (2020, May). Isolation and Characterization of a New Phage Infecting Elizabethkingia anophelis and Evaluation of Its Therapeutic Efficacy in vitro and in vivo. Frontiers in Microbiology , 11:728. 本人為第一作者.
13. Tina Tuwen Chen,†, Shih yi Peng,†, Yan juan Wang, Yuan Hu, Yu juan Shen, Yu xin Xu, Jian hai Yin, Cong shan Liu and Jian ping Cao (2019, Oct). Improvement of Mitochondrial Activity and Fibrosis by Resveratrol Treatment in Mice with Schistosoma japonicum Infection. Biomolecules, 9(11):1-19. 本人為 第一作者. 共同第一作者.
14. Ming-Hong Lin, Kin-Mu Lee, Che-Yuan Hsu, Shih-Yi Peng , Ching-Nan Lin, ⁎ Chin-Chu Chen, Chia-Kwung Fan, Po-Ching Cheng⁎ (2019, Aug). Immunopathological effects of Agaricus blazei Murill polysaccharides against Schistosoma mansoni infection by Th1 and NK1 cells differentiation. International Immunopharmacology, 73, 502-514. 本人為通訊作者. 共同通訊 作者.
15. T.T.W. Chen, P.C. Cheng, K.C. Chang, J.P. Cao, J.L. Feng, C.C. Chen, H.Y.P. Lam and S.Y. Peng (2019, Aug). Activation of the NLRP3 and AIM2 inflammasomes in a mouse model of Schistosoma mansoni infection. Journal of Helminthology, 94:1-9. 本人為通訊作者.
16. Shinn Jong Jiang, Pei I Tsai, Shih Yi Peng, Chun Chun Chang, Yi Chung, Hao Hsiang Tsao, Hsin Ting Huang, SanYuan Chen, Hao Jen Hsu (2019, Feb). A potential peptide derived from cytokine receptors can bind proinflammatory cytokines as a therapeutic strategy for antiinflammation. Scientific Reports ,9:2317:1-15.
17. Chin-Hao Yang, Yi-Cheng Chen, Shih-Yi Peng, Andy Po-Yi Tsai, Tony Jer-Fu Lee, Jui- HungYen & Je-Wen Liou (2018, Oct). An engineered arginine-rich αhelical antimicrobial peptide exhibits broad-spectrum bactericidal activity against pathogenic bacteria and reduces bacterial infections in mice. Scientific Reports, 8:p.14602~p.14602.
18. Peng SY, You RI, Lai MJ, Lin NT, Chen LK, Chang KC. (2017, Sep). Highly potent antimicrobial modified peptides derived from the Acinetobacter baumannii phage endolysin LysAB2. ScientIfic reports, Sep 13;7(1):11477. doi: 10.1038/s41598-017-11832-7.. 本人為第一作者.
19. Peng J, He ZP, Zhang S, Lun ZR, Wu ZD, Fan CK, Brown CL, Cheng PC, Peng SY, Yang TB. (2017, Aug). Phylogeography of Angiostrongylus cantonensis (Nematoda: Angiostrongylidae) in southern China and some surrounding areas. PLOS Neglected Tropical Diseases, 2017 Aug 21;11(8):e0005776. doi: 10.1371/journal.pntd.0005776..
20. Kae-Maw Wang, Teng-Yi Lin, Kai-Chih Chang, Min-Jen Shieh, Ding-Guo Liu, Shih-yi-Peng* (2017, Apr). Epidemiology of Enterobius vermicularis infection among elementary school children in Hualien Taiwan in 2007-2011. Tropical Biomedicine , 34(1): 143–149 (2017). 本人為通訊作者.
21. Cheng PC, Lin CN,3, Peng SY, Kang TF, Lee KM. (2016, Feb). Combined IL-12 Plasmid and Recombinant SjGST Enhance the Protective and Anti-pathology Effect of SjGST DNA Vaccine Against Schistosoma japonicum. PLOS Neglected Tropical Diseases, 10(2); 1-19.
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